SoiCarby Capsule, Hard

Omeprazole 20mg + Sodium bicarbonate 1100mg

40 mg + 1100 mg

ALPHA PHARMA INDUSTRY

Pack size	28's Pack
Dispensing mode
Source
Agent
Retail Price	3.13 AED

Indications

SoiCarby Capsule, Hard is used for: Peptic ulcer disease, Gastroesophageal Reflux Disease (GERD), Erosive Esophagitis

Adult Dose

Oral Usually once daily on an empty stomach, at least 1 hour before a meal.

Child Dose

Safety and efficacy not established

Renal Dose

Administration

Contra Indications

Patients with known hypersensitivity to any components of the formulation.

Precautions

Exclude malignancy, prolonged use, hepatic impairment. Pregnancy, lactation, children <1 yr. Lactation: Distributes into human breast milk; avoid use

Pregnancy-Lactation

Interactions

Omeprazole: Increased risk of hypomagnesaemia w/ diuretics. May increase INR and prothrombin time w/ warfarin. Increased risk of digoxin-induced cardiotoxic effects. May increase plasma concentration benzodiazepines (e.g. diazepam), clarithromycin and methotrexate. Decreased absorption of itraconazole, ketoconazole, posaconazole, dasatinib, iron salts. May prolong elimination of diazepam, cilostazol, phenytoin and ciclosporin. May reduce the antiplatelet effect of clopidogrel. Potentially Fatal: May decrease plasma concentrations and pharmacological effects of rilpivirine, nelfinavir and atazanavir. Sodium bicarbonate: Increases toxicity of amphetamines, ephedrine, pseudoephedrine, flecainide, quinidine and quinine. Decreases effects of lithium, chlorpropamide and salicylates due to increased clearance. May affect the absorption of certain drugs due to raised intra-gastric pH.

Adverse Effects

Side effects of Omeprazole 20mg + Sodium bicarbonate 1100mg : >10% Pyrexia (20%), Hypokalemia (12%), Hyperglycemia (11%), Nosocomial pneumonia (11%) 1-10% Hypotension (10%), Hypomagnesemia (10%), Hypertension (8%), Atrial fibrillation (6%), Hypocalcemia (6%), Rash (6%), Tachycardia (5%), Constipation (5%), Sepsis (5%), Hyperpyrexia (5%), Oral candidiasis (4%), Bradycardia (4%), Diarrhea (4%), Edema (3%), Supraventricular tachycardia (3%), Decubitus ulcer (3%), Agitation (3%), Hypernatremia (2%), Hyperkalemia (2%), Urinary tract infection (2%), Hypomotility (2%), Candidal infection (2%) <1% Angina, Fracture, Glycosuria, Anemia, Hepatic failure, Benign gastric polyps, Agranulocytosis, Alopecia, Increased creatinine, Hemolytic anemia, Angioedema, Gynecomastia, Anorexia, Hepatic encephalopathy, Metabolic alkalosis, Pancreatitis, Photosensitivity, Liver disease Potentially Fatal: Anaphylaxis.

Mechanism of Action

Omeprazole is a substituted benzimidazole gastric antisecretory agent and is also known as PPI. It blocks the final step in gastric acid secretion by specific inhibition of H+/K+ ATPase enzyme system present on the secretory surface of the gastric parietal cell. Both basal and stimulated acid are inhibited. Sodium bicarbonate raises blood and urinary pH by dissociation to provide bicarbonate ions, which neutralises the hydrogen ion concentration. It also neutralises gastric acid via production of carbon dioxide.

Note

SoiCarby 40 mg + 1100 mg Capsule, Hard manufactured by ALPHA PHARMA INDUSTRY. Its generic name is Omeprazole 20mg + Sodium bicarbonate 1100mg. SoiCarby is availble in Saudi Arabia. Farmaco SA drug index information on SoiCarby Capsule, Hard is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Omeprazole 20mg + Sodium bicarbonate 1100mg :

Capsule

OMIZ PLUS ^{20 mg + 1100 mg}

ABBOTT FRANCE

Capsule

GASTROZOLE PLUS ^{40 mg + 1100 mg}

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GASTROZOLE PLUS ^{20 mg + 1100 mg}

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Capsule, Hard

Omezyn Plus ^{40 mg + 1100 mg}

OMAN PHARMACEUTICAL PRODUCTS CO. L.L.C